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Technical Support Staff

Image by Giu Vicente

Marike van Gisbergen

Associate Scientist

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Kim Savelkouls

(Group Rouschop/Kampen)

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Jolanda Piepers

(Group Vooijs)

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Tessa Welbers

(Group De Ruysscher)

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Reitske Borman 

(Group Vooijs)

Group Marc Vooijs

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Somaieh Ahmadian

PostDoc

Marloes Jonkhout

PostDoc

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In my project we aim to identify new resistance mechanisms for the widely used chemotherapy, Temozolomide in glioblastoma patients. We are specifically interested in the spatial en longitudinal heterogeneity of the DNA-repair protein MGMT and its relation to the tumour micro-environment. The ultimate goal of my project is to find new therapeutic targets to combat treatment resistance and extend the lives of glioblastoma patients.

Mike van Heumen
MD, PhD-student

Linde Hoosemans

MD, PhD-student

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For my PhD we use patient-derived GBM organoids to investigate resistance mechanisms against small molecule inhibitors and the difference in photon and proton irradiation.

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To study potential treatments for vestibular schwannoma (VS), a patient-derived in vitro model which recapitulates the original tumour characteristics is preferred. Currently, 2D cell cultures of VS cells are typically used in VS preclinical models. My PhD project is focused on the development and optimalization of a 3D patient-derived in vitro VS model.  

Josselien Meijvogel

MD, PhD-student

Rui Zhang

PhD-student

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My reasearch is focused on NOTCH signaling. We found that DMT1, an iron transporter, can modulate notch signaling and KO DMT1  makes  lysosome become leaky. I focus on the study of  how DMT1 influences the notch pathway and why lysosome becomes leaky. In addition, there are different DMT1 isoforms, which might play different roles in the regulation of notch. These findings might deepen our understanding of notch modulation and help us find some potential treatment strategies towards cancer.

Group Kasper Rouschop

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Tom Keulers

Senior Scientist

Jinzhe Ju

PhD-student

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My project focuses on extracellular vesicle biogenesis. We aim to uncover the mechanism and key factors involved in this process under hypoxic conditions. To navigate through the uncertainties, we employ various molecular cell biology techniques, as well as high-resolution microscopy for image processing and analysis of fixed or live cells.

Joël Beaumont

PhD-student

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In my project, we investigate how cancer cell derived extracellular vesicles (EV) contribute to tumour progression. EV are small membrane particles which contain a variety of proteins, lipids and nucleic acids which are secreted for inter-cellular communication. We demonstrate their involvement in various hallmarks of cancer, including the induction of angiogenesis, metabolic reprograming and the development of metastases. Understanding the role of EV in these processes could uncover new therapeutic targets to suppress tumour progression.

Lydie Barbeau

PhD-student

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Most solid human tumors contain regions that are poorly oxygenated. Tumor hypoxia is a very heterogeneous and dynamic feature and is associated with a more aggressive phenotype due to increased resistance to chemo- and radiotherapy. Essential for the survival of hypoxic cells, is the activation of autophagy. We study the relevance of clinically available drugs to elevate autophagy-dependence of hypoxic tumor cells, to then increase therapeutic benefit in glioblastoma.

Group Kim Kampen

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Judith Hounjet

PostDoc

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Anaís Sánchez Castillo 

PhD-student

Group Dirk de Ruysscher

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Rianne Vaes

PostDoc

Shaowen Lyu

MD, PhD-student

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I mainly focus on the irradiation-induced immune response in non-small cell lung cancer, including how the dendritic cells behave in  lung tumor environment during treatment, differences of immune responses induced by photon and proton irradiation on lung cancer cells and a novel patient-derived ex vivo prediction culture model to predict treatment responses of clinical patients.

Students year 2023-2024

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Lourdes Matas Sancho

(Group Vooijs)

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Mart Smidt

(Group Vooijs)

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Erik Meyer

(Group Rouschop)

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Diego Fadrique Valle

(Group Rouschop)

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