Marc Vooijs, is chair of the Department Radiotherapy and programme leader Basic and Translational Cancer Biology program at the GROW research Institute for Oncology. He did his Ph.D. in the Netherlands Cancer Institute with A. Berns and his postdoctoral work at Washington University in Saint Louis with Raphael Kopan and in the Hubrecht Institute with Hans Clevers. In 2006 he started his own group at the Department of Pathology at the UMC- Utrecht (Head Prof P. van Diest). In 2010 he moved to the MUMC+ to become head laboratory research at the Department of Radiation Oncology. In 2012 he was elected a member of the Young Academia Europe (YAE). His work is supported by the ERC, AICR (WCR) and Dutch Cancer Society (KWF).
His research is focused on mechanistic insight into signal transduction by NOTCH family proteins and their context-dependent role in stem cells, cancer development and treatment response, with an emphasis on tumor microenvironment and hypoxia.
Kasper Rouschop is an associate professor and group leader at the department of radiotherapy. He obtained his Ph.D. in nephrology at the University of Amsterdam in 2006 with Sandrine Florquin, Jan J. Weening, and Steven T. Pals. Currently, he is the principal scientist of a group focused on unraveling the role of hypoxia-induced autophagy and further exploit this to improve cancer therapy.
In the past years he received prestigious grants for personal funding (VENI (2007), KWF (2012)) and project funding (KWF (2010 and 2015), STOPhersentumoren.nl (2013), WWCR (2015)) as principal investigator. His recent interests are unravelling the mechanisms of hypoxia-induced autophagy and related mechanisms to exploit this knowledge for improvement of treatment efficacy. Results obtained have lead to an investigator driven phase I/II trial in patients suffering from small cell lung cancer (SCLC) and glioblastoma multiforme (start in summer 2016).
Kim Kampen is an assistant professor and group leader at the department of radiotherapy. During her Ph.D. (2013-2015), Kim worked with Prof. de Bont (University of Groningen) on the role of vascular endothelial growth factors in pediatric acute myeloid leukemia. From June 2015 onwards, she performed postdoctoral research at the Catholic University (KU Leuven, Belgium) with Prof. Kim De Keersmaecker, studying the role of ribosomal gene defects in cancer. She identified the so called “oncoribosomes”, mutant ribosomes that have specific advantageous translational capacities in T-cell leukemia. Kim showed that RPL10 R98S mutant ribosomes accumulated on a serine synthesis enzyme to induce its translation, which fuels downstream purine synthesis to support leukemia progression in vivo (Kampen et al. Nature Communications 2019). Her current research is focused on the identification of new molecular mechanisms of serine/glycine synthesis upregulation in cancer, which allows building a patient stratification framework for cancers that can benefit from serine synthesis inhibiting compounds. She received several awards for her research, including the ASH abstract award in 2013, LTMT award for leukemia research in 2016, the AACR-Pezcoller Foundation Scholar-in-Training Award in 2017, and the Rimaux Bartier donation award for best-ranked postdoctoral researcher in 2018
Tom Keulers (Autophagy)
Violeta Mendez Ovares
Anaís Sánchez Castillo
Kim Savelkouls (Autophagy)
Jolanda Piepers (NOTCH)
Marijke Zonneveld, PhD (Autophagy)