Copyright © 2014 | Maastricht Radiation Oncology Lab Maastricht University / MUMC

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m-Group

We develop and validate molecular and/or imaging biomarkers that will be integrated in clinical multifactorial Decision Support Systems. We test and select promising new molecular radiosensitizing therapeutic agents with the view to test them in early clinical trials

 

Recent key papers

 

Rekers NH, Zegers CM, Germeraad WT, Dubois L, Lambin P. Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2. Oncoimmunology. 2015 Apr 2;4(8):e1021541. eCollection 2015 Aug
Trani D, Yaromina A, Dubois LJ, Granzier M, Peeters SG, Biemans R, Nalbantov G, Lieuwes NG, Reniers BR, Troost EG, Verhaegen F, Lambin P. Preclinical assessment of efficacy of radiation dose painting based on intratumoral FDG-PET uptake. Clin Cancer Res. 2015 Aug 14. pii: clincanres.0290.2015. [Epub ahead of print]
Peeters SG, Zegers CM, Biemans R, Lieuwes NG, van Stiphout RG, Yaromina A, Sun JD, Hart CP, Windhorst AD, van Elmpt W, Dubois LJ, Lambin P. TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging. Clin Cancer Res. 2015 Jul 1;21(13):2984-92. doi: 10.1158/1078-0432.CCR-15-0018. Epub 2015 Mar 24.

Group members

 

Team leaders

 

Ludwig Dubois

Philippe Lambin

 

Post-Docs

 

Ala Yaromina

“Efficacy of various heterogeneous irradiation approaches based on FDG uptake, hypoxia and drug uptake”

Marike van Gisbergen

"Mitochondrial genetics for the prediction of radiotherapy-induced lung toxicity risk: a prospective multicentre and mechanistic study"


PhD students

 

Damienne Marcus

"Radiotherapy and immunotherapy"

Veronica Olivo Pimentel

Radiotherapy combined with immunotherapy: pushing the accelerator or releasing the brake?

Alexander van der Wiel

Immunotherapy and hypoxia-activated prodrugs

Relinde Lieverse

ImmunoSABR


Research technicians

 

Natasja Lieuwes 

 

Rianne Biemans 

 

Alumni

Raymon Niemans 

“Hypoxic CAIX as a target for imaging and cancer treatment with radiotherapy and novel drugs”

Linda Spiegelberg

"Hypoxia activated prodrugs in esophageal cancer"

Nanda Kumar Parvathaneni

"CAIX small molecule inhibitors"

Marike van Gisbergen

“Do our mother’s genes influence response to radiotherapy: a genetic and pharmacological approach?”

Nicolle Rekers 

“Combining immunotherapy approaches with irradiation: a successful story?”

Auke Otten

mtDNA variations for predicting radiation-induced normal tissue toxicity

Sarah Peeters

"The hypoxic tumor microenvironment from imaging to targeting"

Simon van Kuijk 

“Hypoxic CA IX as a target for cancer treatment with radiotherapy and bifunctional drugs“

Kranthi Panth 

“Role of Matrix metalloproteinases in solid cancers: target validation and developing new preclinical imaging biomarkers for aggressive cancers”

Maud Starmans  

“Bioinformatics in cancer”

Grants

 

 

Combination of chemoradiotherapy with the hypoxia-activated pro-durg TH-302

Grant# 15-0345

Period: 2015-2017

Project coordinator: Dr. Ludwig Dubois

Sum awarded: 260 K€

Funded by: World Wide Cancer Research (formerly AICR)

 
Hypoxic CAIX as a target for imaging and cancer treatment with radiotherapy

Grant# UM 2012-5394

Period: 2012-2016

Project coordinators: Prof. Philippe Lambin, Dr. Ludwig Dubois

Sum awarded: k€ 560

Funded by: KWF project grant

 

Toxicity study and GMP production of a dual drug composed of two covalently bound moieties: Carbonic Anhydrase IX inhibitor and nitroimidazole

Grant# MAC 2013-6089

Period: 2013-2017

Project coordinators: Prof. Philippe Lambin, Dr. Ludwig Dubois

Sum awarded: k€ 568

Funded by: KWF additional support grant

 

Reduction of radiation-induced lung fibrosis with BIBF1120

Grant# 43040512

Period: 2012-2014

Project coordinators: Dr. Ludwig Dubois

Sum awarded: k€ 300

Funded by: Boehringer Ingelheim

 

Therapeutic Gain Assessment with TrueBeam-based Boost of Biological Target Volumes: a Rat Tumour Model Study

Grant# 01

Period: 2012-2014

Project coordinators: Prof. Philippe Lambin, Dr. Ludwig Dubois

Sum awarded: k€ 150

Funded by: Varian

 

Exploiting intra tumour heterogeneity with heterogeneous irradiation: a combined preclinical and clinical approach - The example of lung cancer

Grant# 

Period: 2012-2016

Project coordinators: Prof. Philippe Lambin, Dr. Ludwig Dubois

Sum awarded: k€ 360

Funded by: Kanker OnderzoeksFonds Limburg

 

24 Gy per minute or 5 Gy per minutes: Does the DNA repair status of the cell matter?

Grant# 02

Period: 2012-2013

Project coordinators: Prof. Philippe Lambin

Sum awarded: k€ 60

Funded by: Varian

 

DualTPharma 2013: novel carbon anhydrase inhibitors to develop targeted lung cancer therapy

Grant# 40-41300-98-12024

Period: 2013-2015

Project coordinators: Prof. Philippe Lambin, Dr. Ludwig Dubois

Sum awarded: k€ 250

Funded by: NGI-PreSeed

 

IXhibit: Development of a novel dual CAIX inhibitor as treatment strategy for lung cancer

Grant# 200909705-20130020213

Period: 2013-2015

Project coordinators: DualTPharma

Sum awarded: k€ 250

Funded by: Interreg IVA project GCS

 

Development of Bimodal MRI/PET imaging agents for imaging of hypoxia: the best of both worlds

Grant# APP1058222

Period: 2014-2016

Project coordinators: Dr. Sally-Ann Poulsen, Philippe Lambin, Dr. Ludwig Dubois

Sum awarded: k$ 200

Funded by: Cancer Council Queensland

 

Toediening van Rapamycin gecombineerd met preoperatieve bestraling bij patiënten met een tumor in de endeldam: een fase I-II studie

Grant # PF 227

Period: 2008-2010

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 108k€

Funded by: AzM Profileringsfonds

 

Non invasive imaging of EGFR expression with Cetuximab-Zirconium, a new PET marker

Grant # UM 2008-4210

Period: 2008-2012

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 195k€

Funded by: KWF kankerbestrijding KGO

 

Metastatic tumours facilitated by hypoxic tumour micro-environments (METOXIA)

Grant #222741

Period: 2008-2014

Project coordinator: Prof. Dr. Philippe Lambin, Prof. dr. Brad Wouters

Sum awarded: 472k€ Lambin MC, 438k€ Wouters UM

Funded by: EU FP7

 

Hypoxic regulation of ER stress responses and their exploitation for cancer therapy

Grant # UM 2008-4068

Period: 2008-2012

Project coordinator: Prof. Dr. Brad Wouters

Co-Investigator: Prof. Dr. Philippe Lambin

Sum awarded: 479k€

Funded by: KWF

 

Personalized chemo-radiation of lung and head and neck cancer (AIRFORCE)

Grant # 03O-103

Period: 2008-2013

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 1,7M€

Funded by: CTMM

 

A Euregional Computer Assisted Theragnostics network (EUROCAT)

Grant # EMR.INT4 1.2.2009-04/049

Period: 2010-2014

Project coordinator: Prof. Dr. Philippe Lambin, Dr A. Dekker

Sum awarded: 589k€ MC, 321k€ UM

Funded by: EFRO, INTERREG IV-A

 

Quantitative Imaging in Cancer: Connecting Cellular Processes with Therapy (QuIC-ConCePT)

Grant # 115151

Period: 2011-2015

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 550k€

Funded by: EU, IMI ju

 

Bloodimaging: Prediction of survival in Non Small Cell Lung Cancer using blood markers and imaging features: Hypothesis driven approach with prospective validation

Grant # UM 2011-5020

Period: 2011-2015

Project coordinator: Prof. Dr. Philippe Lambin, Dr. Ludwig Dubois

Sum awarded: 529k€

Funded by: KWF

 

Hypoxic CAIX as a target for imaging and cancer treatment with radiotherapy

Grant # UM 2012-5394

Period: 2012-2016

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 530k€

Funded by: KWF

 

Using mtDNA variants in predicting radiation-induced lung toxicity in patients that undergo radiotherapy

Grant # 93612005

Period: 2012-2014

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 250k€

Funded by: NGI

 

Exploiting intratumour heterogenety with heterogeneous irradiation

Grant # -

Period: 2013-2017

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 320k€

Funded by: KOFL

 

DualTPharma: novel CAIX to develop targeted lung therapy

Grant # 93613002

Period: 2013-2015

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 250k€

Funded by: NGI

 

Toxicology, pharmacological evaluation and GMP production of CAIX

Grant # UM 2013-6089

Period: 2014-2018

Project coordinator: Prof. Dr. Philippe Lambin

Sum awarded: 568k€

Funded by: KWF

 

 

 

 

Please follow this link to see all the grants received by MaastroLab