Copyright © 2014 | Maastricht Radiation Oncology Lab Maastricht University / MUMC

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Autophagy

We study hypoxia-induced autophagy and related processes, to exploit this knowledge for improved cancer treatment

 

Key papers

 

GABARAPL1 is required for increased EGFR membrane expression during hypoxia. Keulers TG #, Schaaf MBE#, Peeters HJ, Savelkouls KG, Vooijs MA, Bussink J, Jutten B, Rouschop KM. Radiother Oncol. 2015 2015 Sep;116(3):417-22
Jutten B, Keulers TG, Schaaf MB, Savelkouls KG, Theys J, Span PN, Vooijs MA, Bussink J, Rouschop KM: EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival. Radiother Oncol. 2013 Sep;108(3):479-83
 
Schaaf MB, Cojocari D, Keulers TG, Jutten B, Starmans M, Jong MD, Begg A, Savelkouls KG, Bussink J, Vooijs M, Wouters BG, Rouschop KM: The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia. Radiother Oncol. 2013 Sep;108(3):529-34
 
Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M, Wouters BG. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest. 2010 Jan 4;120(1):127-41
 
 
 

Grants

 

Please follow this link to see all the grants received by MaastroLab

Group Members

 

Autophagy associated extracellular vesicles in glioblastoma multiforme: new players in hypoxia-associated tumour progression?

Period: 2016-2019

Funded by: Worldwide Cancer Research (formerly AICR)

Sum of contract in Euro’s: € 295.000

 

Hypoxia associated exosomes: a new target in hypoxia-associated tumour aggressiveness? 

Period: 2015-2019

Funded by: KWF project grant

Sum of contract in Euro’s: € 563.100

Hypoxia-induced autophagy: a therapeutic target for cancer therapy?

# UM 2010-4714

Period: 2010-2014 

Project coordinator: Dr. Kasper Rouschop 

Funded by: KWF 

Sum Awarded: € 486.000

 

Autophagy signaling, an essential requirement for tumor microenvironment maintenance and therefore a therapeutic target

#UM 2012-5506

Project coordinator: Dr. Kasper Rouschop 

Period: 2012-2018 

Funded by: KWF personal funding

Sum Awarded: € 524,000

 

Therapeutic opportunity of autophagy inhibition in the treatment of EGFRvIII expressing glioblastoma multiforme.

Project coordinator: Dr. Kasper Rouschop

Period 2013-2015

Funded by: STOPhersentumoren.nl/zeldzame ziekten fonds (STOPbraintumors.nl /rare diseases fund):

Sum awarded: €147,000

 

 

Team leader
 
Kasper Rouschop PhD
 
 
Post-Docs
 
Marijke Zonneveld
PhD Students
 
Tom Keulers, MSc
 
Technicians
Kim Savelkouls, Ing
Alumni
Barry Jütten
Marco Schaaf (KU Leuven)