Copyright © 2014 | Maastricht Radiation Oncology Lab Maastricht University / MUMC

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We study hypoxia-induced autophagy and related processes, to exploit this knowledge for improved cancer treatment


Key papers


GABARAPL1 is required for increased EGFR membrane expression during hypoxia. Keulers TG #, Schaaf MBE#, Peeters HJ, Savelkouls KG, Vooijs MA, Bussink J, Jutten B, Rouschop KM. Radiother Oncol. 2015 2015 Sep;116(3):417-22
Jutten B, Keulers TG, Schaaf MB, Savelkouls KG, Theys J, Span PN, Vooijs MA, Bussink J, Rouschop KM: EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival. Radiother Oncol. 2013 Sep;108(3):479-83
Schaaf MB, Cojocari D, Keulers TG, Jutten B, Starmans M, Jong MD, Begg A, Savelkouls KG, Bussink J, Vooijs M, Wouters BG, Rouschop KM: The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia. Radiother Oncol. 2013 Sep;108(3):529-34
Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M, Wouters BG. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest. 2010 Jan 4;120(1):127-41



Please follow this link to see all the grants received by MaastroLab

Group Members


Autophagy associated extracellular vesicles in glioblastoma multiforme: new players in hypoxia-associated tumour progression?

Period: 2016-2019

Funded by: Worldwide Cancer Research (formerly AICR)

Sum of contract in Euro’s: € 295.000


Hypoxia associated exosomes: a new target in hypoxia-associated tumour aggressiveness? 

Period: 2015-2019

Funded by: KWF project grant

Sum of contract in Euro’s: € 563.100

Hypoxia-induced autophagy: a therapeutic target for cancer therapy?

# UM 2010-4714

Period: 2010-2014 

Project coordinator: Dr. Kasper Rouschop 

Funded by: KWF 

Sum Awarded: € 486.000


Autophagy signaling, an essential requirement for tumor microenvironment maintenance and therefore a therapeutic target

#UM 2012-5506

Project coordinator: Dr. Kasper Rouschop 

Period: 2012-2018 

Funded by: KWF personal funding

Sum Awarded: € 524,000


Therapeutic opportunity of autophagy inhibition in the treatment of EGFRvIII expressing glioblastoma multiforme.

Project coordinator: Dr. Kasper Rouschop

Period 2013-2015

Funded by: ziekten fonds ( /rare diseases fund):

Sum awarded: €147,000



Team leader
Kasper Rouschop PhD
Marijke Zonneveld
PhD Students
Tom Keulers, MSc
Kim Savelkouls, Ing
Barry Jütten
Marco Schaaf (KU Leuven)