MAASTRO (Maastricht Radiation Oncology), is an integrated institute combining a state of the art radiation oncology (Maastro Clinic) with interdisciplinary clinical, translational and basic research in physics and biology. Maastro Clinic is the largest Radiotherapy clinic in southeast of the Netherlands treating around 4000 patients every year. Maastro Clinic is one of four locations in the Netherlands which have received a permit to build a proton therapy center.
Research and training is carried out in 5 divisions: Maastro Physics (dr Frank Verhaegen), Maastro Trials (dr Dirk de Ruysscher), Maastro Knowledge Engineering (dr Andre Dekker) , Maastro School and E-learning and Maastro Lab (dr Marc Vooijs). Maastro Lab is a basic science and translational research laboratory embedded within the Research School GROW and the Faculty of Health Medicine and Life Sciences at Maastricht University.
The vision of Maastro Lab is to translate basic research findings into clinical research aimed at improving cancer diagnosis and treatment.
The strategic focus is the elucidation of the signalling pathways and mechanisms in the tumor and it’s microenvironment that contribute to treatment sensitivity in cancer cells and protection of normal tissues and to develop drugs to modulate these in patients.
Research in Maastro Lab is fully integrated in translational/clinical research carried out in Maastro Clinic with an emphasis on non small cell lung cancer and glioblastoma. Several investigator initiated phase I trials have been initiated.
Maastro Lab has a state of the art preclinical mouse cancer model pipeline with different cancer models (spontaneous, orthotopic and patient derived xenografts) and a small animal irradiator with onboard microCT and BLI; and has access to several non-invasive small animal imaging modalities (BLI, FLI, uPET, uSPECT, uMRI.